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Author
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Sherry
Jung
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Biological
Sciences
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The
hardships and obstacles Sherry Jung faced during the course
of her research project all seemed to melt away the day she
finally obtained significant and reproducible results. Her contribution
to the advancement of dermatology is only one of Sherrys
many accomplishments. During her time at UCI, she has been an
HSEP Medical Volunteer, a Peer Educator for the Counseling Center,
and has served as a Biological Sciences Representative on the
ASUCI Legislative Council. She is also a founding member and
the current editor-in-chief of Med Times. Sherrys
advice to future undergraduate researchers is to start early,
learn from your mistakes, be patient, and stay motivated.
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Abstract
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The role of the skin
is to provide a barrier to the external environment, rendering
absorption of therapeutic drugs, including corticosteroids,
problematic. Preliminary testing has shown that fatty acids
(linoleic acid) incorporated into structurally configured polymers
can act as penetration enhancers. This modification alters the
barrier properties of the stratum corneum and the migration
of topical drugs such as cortisol through human skin. Previous
unpublished studies using an amine compound, polyoxyalkyleneamine
D 400 (polyamine D 400), have suggested that topical corticosteroid
solutions supplemented with novel polymers improve the penetration
of therapeutic drugs. Sets of unique polymers, synthesized in
this laboratory, were selected for initial assessment of penetration
enhancement using the in vitro Franz diffusion model.
The penetration and retention of cortisol into the skin layers
were determined by measuring radiolabeled drug levels at the
experimental endpoint by liquid scintillation counting. Linoleic
acid + polyamine D 400 polymer achieved statistically higher
cortisol penetration through the skin when compared to the commercial
standard or the vehicle control. In the future, these unique
polymers may be used as penetration enhancers to improve transdermal
delivery of other topical drugs of therapeutic interest.
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Faculty
Mentor
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The rewards and experiences
derived from mentoring undergraduate students through the School
of Biological Sciences are mutual. The skills acquired through
participation in research programs at UCI carry over into our
students professional lives, and their publications help
to further their career development. The current project by
Sherry Jung has served to illuminate our understanding of the
penetration of a common dermatological drug when used in combination
with a custom-synthesized polymer. The results obtained point
to direct applications in the field of dermatology as the polymeric
compounds may be further modified for targeted-drug delivery.
The avenues of research in this area are numerous, and we anticipate
ongoing investigations using novel polymeric penetration enhancers.
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If
you wish to view the paper in its entirety, please select
the link given to the PDF file. [Sherry
Jung.pdf]
If you wish to download the Adobe Acrobat Reader,
please go to Adobes website (www.adobe.com).
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