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Author
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Anna
Litmanovich
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Neurobiology
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Without
question, Anna Litmanovich is a Renaissance woman.
Her first four years of school were spent studying piano in
Uzbekistan, the country of her birth. Since coming to the United
States, Anna has excelled in both the arts and sciences. For
the past six years she has performed for Opera Pacific in Costa
Mesa, appearing in nine operas and one ballet. While at UCI,
she has investigated the effects of drugs and hormones on memory
storage and has tutored students ranging from adopted Russian
children who cannot speak English to fellow undergraduates in
such fields as math, psychology, physics, and biology. If thats
not enough, she also plays competitive tennis. Anna hopes to
pursue a career in academic medicine.
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Abstract
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The basolateral amygdala
(BLA) is the putative site for integration of neuronal and hormonal
signals for emotional learning and memory. The present study
explored which muscarinic receptor type(s) (M1, M2 or both)
mediates the critical cholinergic activation in the BLA during
memory-modulating processes. Sprague-Dawley rats were implanted
with bilateral cannulae aimed at the BLA and then trained on
an inhibitory avoidance (IA) task. To selectively activate each
receptor type, selective antagonists, methoctramine or telenzipine
(50 nmol per side), were co-infused with a general muscarinic
receptor agonist, oxotremorine, to stimulate M1 or M2 receptors,
respectively. Oxotremorine (50 nmol per side) was infused alone
to stimulate both receptor types. A single trial IA task was
used in combination with immediate post-training drug treatments
so that the consolidation phase of memory could be selectively
manipulated. The mean retention latency of oxotremorine-only
group in the 48-hr retention test was significantly higher than
the mean retention latencies of the groups that received co-infusion
of telenzipine or methoctramine with the oxotremorine. These
findings indicate that both muscarinic receptor types need to
be activated in order for memory enhancement to occur.
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Faculty
Mentor
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Animals have evolved
the amazing ability to store memory better for emotionally significant
events. This ability depends on a convergence of hormonal and
neurochemical signals in a small region of the medial temporal
lobe of the brain called the basolateral amygdala (BLA). The
neurotransmitter acetylcholine has been found to play a critical
role in BLA modulation of memory storage via activation of muscarinic
receptors. This project was the first analysis of the muscarinic
receptor subtypes, which mediate this cholinergic activation
of the BLA during consolidation. In collaboration with researchers
from my laboratory, including Dr. Ann E. Power, who was directly
responsible for guiding Annas research, Anna learned that
cholinergic modulation of memory involves activation of both
excitatory and inhibitory receptor systems in the BLA. These
findings enhance our understanding of the neurobiological mechanisms
of modulation of memory storage by emotion and arousal.
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If
you wish to view the paper in its entirety, please select
the link given to the PDF file. [Anna
Litmanovich.pdf]
If you wish to download the Adobe Acrobat Reader,
please go to Adobes website (www.adobe.com).
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