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Author
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Aaron C. Abajian
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Biological Sciences,
Computer Science & Engineering,
and Mathematics
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Aaron
Abajian has devoted his undergraduate research experience
to developing computer tools for use in biology. For this
project, under the mentorship of Professor Lowengrub, Aaron
has combined the fields of computer science, biology and
mathematics to create a unique mathematical tumor model.
He has found the novelty of his project particularly exciting,
especially as it has helped him truly understand many difficult
concepts for the first time. Aaron is currently enrolled
in a Credential and Master’s Program in Urban Education
at Loyola Marymount University, while teaching high school
as part of the Teach for America Program.
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Abstract
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Tumor
development is a complex and multi-faceted process that cannot
be captured in a single formula, yet the ability to predict
a maturing tumor’s magnitude and direction of growth
would provide significant clinical benefits. In-vitro trials
provide only limited predictive data since it is nearly impossible
to chemically reproduce the exact environmental conditions
surrounding a tumor. Moreover, each trial is necessarily
unique to a specific tumor and cannot be quickly modified
to satisfy the requirements of another. Mathematical models
provide a virtual solution to this problem by implementing
the core processes of tumor development in software. We present
a model for tumor development from the single-cell stage
to early microinvasion. An overlying nutrient field determines
a cell’s status as living, quiescent, mutant, or nonviable.
Interactions between tumor cells are simulated using a competing
exponential function and nutrient influx is modeled using
the diffusion equation. The object-oriented implementation
allows the introduction of multiple nutrient and chemical
fields. The model may be applied to a variety of emerging
tumors by carefully defining the constants that determine
the tumors’ development pathway and microenvironment.
We present simulation results that demonstrate the flexibility
of the model and its future applicability.
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Faculty
Mentor
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This
research introduces an agent-based model for simulating solid
tumor growth. Mathematical modeling and numerical simulation
have the potential to provide important insight into the
root causes of solid tumor invasion and metastasis. Such
models have been widely used for healthy cells but not for
cancer modeling; however, the mechanisms are thought to be
similar. An important feature of cancer is the communication
and adhesion among the cancer cells and the extracellular
matrix. At the time this research was performed, previous
agent-based models did not consider this effect. Now, several
other models account for these effects, although none consider
the questions asked here. Research projects such as this
provide undergraduates with a unique opportunity to bridge
classroom experience and knowledge with important real world
applications.
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If
you wish to view the paper in its entirety, please select
the link given to the PDF file.
[01_abajian.pdf]
If you wish to download the Adobe Acrobat Reader,
please go to Adobes website (www.adobe.com). |
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© 2008
by the Regents of the University of California. All rights reserved.
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