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Author
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Adam Truong
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Biological
Sciences
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Adam
Truong studied the role of gap junctions in mediating synchronous
membrane potential oscillations in projection neurons in
Drosophila pupae. He then designed experiments using the
more developed and complex neural connections of adult
Drosophila brains and discovered a novel connection between
projection neurons. In 2012, Adam received a Master’s
Degree in Global Medicine from the University of Southern
California, and is currently studying to receive his degree
in medicine from the University of California, Irvine School
of Medicine. He hopes to use both degrees to unite his
twin passions of international public health and allopathic
medicine.
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Abstract
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Chemical
synaptic transmission mediates information transfer between
neurons in the insect antennal lobe and plays an important
role in processing olfactory information. In contrast,
while electrical synapses (gap junctions) play a clear
role in neuronal communication in the mammalian olfactory
bulb, relatively little is known about their role in the
antennal lobe. A recent study reported that electrical
synapses mediated by innexin8 encoded gap junction proteins
form specifically between projection neurons (PNs) that
innervate the same but not different antennal lobe glomeruli
in the intact adult fly brain. The current study showed
correlated membrane potential oscillations between randomly
selected PNs. This led to the hypothesis that gap junctions
are important for synchronizing activity between PN pairs
that innervate both the same and different glomeruli. Recordings
were made from pairs of projection neurons and the dendrites
for each projection neuron were located. This demonstrated
that PN pairs innervating different glomeruli showed correlated
electrical activity even with chemical synaptic transmission
blocked. Correlated activity also was reduced in PN pairs
in innexin8 mutants compared to wildtype. These data show
that innexin8 encoded gap junction proteins are important
in synchronizing activity between PNs that innervate different
and the same antennal lobe glomeruli.
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Faculty
Mentor
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Adam joined the lab in the summer following his freshman year and did research
every quarter until he graduated. Early on he enthusiastically applied
himself to developing the fine micro-dissection skills required to remove
the brain from the head of a tiny fruit fly. Adam then undertook the heroic
task of recording simultaneously from two neurons in a well-defined neural
circuit that processes olfactory information in the fly brain. The data
in his excellent paper demonstrate coordinated activity between two different
neuronal subtypes, revealing a novel pathway of communication between neurons
in this circuit. Adam took full advantage of his time in the lab, learning
do science and to think like a scientist.
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If
you wish to view the paper in its entirety, please select
the link given to the PDF file.
[05_truong.pdf]
If you wish to download the Adobe Acrobat Reader,
please go to Adobes website (www.adobe.com). |
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© 2011
by the Regents of the University of California. All rights reserved.
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